Kiiza David Maclaren

What causes cancer? I am going to attempt to give the shortest, best, detailed description of cancer ever written. ;-) Ready?! Here goes… Cancer is a breakdown in the integrity of the signaling pathways in a group of cells. Signaling pathways are collections of molecules that interact, working together in a sequence, that lead to execution of different routines in your genetic program, to control various cellular functions (e.g. cell division). Computer scientists can think of “signaling proteins” as procedure calls (there is a hierarchical structure to them, just as there is in a computer program). Metaphorically, cancer is a problem with a cell's accelerator and brake. The “accelerator” is the set of signaling pathways that switch on cell growth (cell cycle progression). The “brake” is the set of signaling pathways that instruct a cell to self-destruct for the good of other cells (this is called “apoptosis”). There are two types of signaling proteins in cancer pathway

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